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The Many Dangers Of Excess PUFA Consumption

One of the big differences between Paleo and the typical modern diet is the amount of polyunsaturated fat, or PUFA. Basically, the modern diet has way too much PUFA, and also an imbalance between the two main types of PUFA, Omega-3 and Omega-6.

OK, but what does that mean? Even people who have eaten Paleo for a while aren’t always totally clear, so here’s a look at…

What the Heck is PUFA?

(For Paleo Leap members, there’s also a cheat sheet to break all of this down visually, if you’d rather learn that way! Log in or sign up here.)

A little bit of background: there are three main types of fat. When you eat butter or olive oil or the fat trimmed off a steak, you’re eating some combination of…

(There are a few very minor other types, but we’re keeping it simple for now and these are the big ones).

Some fatty foods are almost completely one type (e.g. coconut oil is 87% saturated). Others are much more mixed (e.g. bacon fat is about 39% saturated, 45% monounsaturated, and 11% polyunsaturated). Here’s an infographic showing some common Paleo cooking fats and which types of fat they provide.

If you look at that infographic carefully, you’ll notice something: all the fats are pretty low in PUFA. There are plenty of high-PUFA fats in this world. Crisco. Soybean oil. Corn oil. Canola oil. “Vegetable oil.” Margarine. But none of them are Paleo, because the last thing we all need in our diets is more PUFA.

So Why is this PUFA Stuff Such a Problem?

The basic difference between these three types of fat is the way they’re structured. Without going into all the biology-nerd details, the structure of PUFAs makes them chemically unstable.

More specifically, PUFAs are very vulnerable to damage from heat, light, and oxygen. If they’re damaged by heat, light, and/or oxygen (for example, if they’re used as frying oil over and over again, or just left out in a clear bottle on the shelf for months in a supermarket), they can get oxidized.

Oxidized fats are dangerous because they’re inflammatory. Eating oxidized fats increases inflammation, and inflammation contributes to just about every chronic disease you could name, including heavy-hitters like obesity and diabetes. For example, in this study, researchers oxidized some soybean oil by heating it up a bunch of times. Then they fed it to rats. The oxidized soybean oil caused inflammation, which raised the rats’ blood pressure and contributed to hypertension. Want another example? This study found that oxidized PUFAs were at the heart of liver damage and Type 2 Diabetes in children with obesity. Drugs that reduce the level of oxidized PUFAs improve liver health.

Even aside from the question of oxidation, the most common type of PUFA in the typical American diet (more on this below) stimulates an inflammatory response all on its own.

All that inflammation is a big player in inflammatory diseases, which happen to be some of the most common diseases around today. Diabetes is an inflammatory disease; so are obesity, metabolic syndrome autoimmune disease, cardiovascular disease, several types of cancers, fatty liver disease, depression…(This isn’t to say that inflammation alone “causes” all these diseases, just that it contributes to them). The list of all the ways inflammation contributes to various diseases would probably fill several books, but if you want more, here’s a starter.

PUFA and the Modern DietPUFA fats

So eating a lot of PUFA is pretty bad news. But in the past few decades, US consumption of PUFA has increased dramatically, from about 3% of total calories in 1909 to about 8% in 1999. The shift happened because we moved away from traditional, low-PUFA cooking fats like butter and towards high-PUFA industrial fats like soybean oil. (Get more background plus some pretty scary charts here).

It’s a serious public health problem, and the irony is that it’s been sold to us as the “healthy choice:” vegetable oil is supposedly better for your heart than all that evil butter! There’s a tiny bit of truth to this idea, but only a tiny little bit. To understand the difference, you have to know about the two types of PUFA.

Omega-3 and Omega-6 PUFA

There are two main types of PUFA: Omega-3 and Omega-6 (also called N-3 and N-6, or w-3 and w-6; these all refer to the same two types of fats).

Today, we don’t just have a simple problem of too much PUFA. We have a complicated problem: too much PUFA in total, and way too much Omega-6, but actually a deficiency of Omega-3s. Our ancestral diets, the ones we evolved to live on, contained Omega-6 and Omega-3 PUFA in a ratio between 4:1 and 1:1. Our modern diets have Omega-6 and Omega-3 PUFA in a ratio closer to 10:1, or even higher.

In general, a high ratio of Omega-6 to Omega-3 is pro-inflammatory, just like too much total PUFA. An imbalance of Omega-6 to Omega-3 harms gut health and may be involved in problems as apparently unrelated as depression, chronic stress, chronic pain, autism spectrum disorders, inflammatory bowel disease, rheumatoid arthritis, and liver disease

…and, of course, cardiovascular disease. Now getting back to the point about heart health: adding O6 and O3 PUFA to the diet improves heart health, but only because it improves the O6:O3 ratio. Correcting that ratio is the key, not some magic effect of adding PUFA. Adding O6 on its own doesn’t help, and might actually hurt. But most of the “heart-healthy” seed oils we’ve been eating are high in Omega-6 PUFA and low in Omega-3. That’s the exact opposite of what we want!

We’re so incredibly deficient in Omega-3s that they benefit us even when they come with extra Omega-6. But you know what would be even better? Improving the ratio of O6 to O3 even more by getting more Omega-3s (from fish and seafood) while reducing Omega-6.

A Quick Recap, for the Confused

This stuff is pretty confusing, so if your head is spinning a little, here’s a recap:

It’s important to stress here that the total amount and the ratio are both important. In other words, you can’t “fix” the problem of O6 overload by drowning yourself in Omega-3 supplements to “balance it out.” Omega-3s can be oxidized just like Omega-6s, and eating oxidized Omega-3s is just as inflammatory. Oxidation is rare if you’re getting your Omega-3s from whole foods like fish, but it’s very common for supplements to be oxidized because they weren’t stored properly or they were just low-quality in the first place.

Practical Advice, or “Just Tell me What to Eat.”


A picture is worth a thousand words, right? Well, here’s what to eat, in picture form!

Today, we get too much total PUFA and in the wrong ratio of O6 to O3. Here’s the Paleo line on how to fix it:

Get less total PUFA:

Improve your ratio of O6 to O3 PUFA:

If you want more science-nerd details, here is a free full-text: it’s a slightly older study so it doesn’t have the very newest research, but it’s good on the basic background.